the psychedelic agent in magic mushrooms, is part of an ongoing clinical trial at Johns Hopkins University. Scientist Roland Griffiths, says we tell people that their experiences may vary from very positive to transcendent and lovely to literally hell realm experiences. Scientist Roland Griffiths and and his colleague Matthew Johnson for the past two decades have been giving what they call “heroic doses” of psilocybin to more than 350 volunteers, many struggling with addiction, depression and anxiety.
Griffiths says the people come to a profound shift of their world view and sense of self. They are less identified with their self-narrative or ego creating a sense of freedom. Study volunteers at Johns Hopkins are given weeks of intensive counseling before and after the six-hour psilocybin experience given in a carefully controlled setting one to three times. One of the things psychedelics do is peel away all our essentially protective levels of irony and, and cynicism we acquire as we get older and you’re back to those kind of “Oh, my God. I forgot all about love.”
Researchers believe that psilocybin quiets these two areas of the brain that normally communicate with each other. They’re part of a region called the default mode network and it’s especially active when we’re thinking about ourselves, our lives, our
identity and loss. The constant voice we have in our heads, chattering at you and criticizing you and telling you what to do, is quieted.
Scientist Matthew Johnson, showed a representational chart of brain activity. To see that rewiring that goes on in the brain. The circle on the left shows normal communication between parts of the brain, on the right, what happens on psilocybin. There’s an explosion of connections or crosstalk between areas of the brain that don’t normally communicate, the difference is startling.